Study of the correlation between the content of polyphenols in different combinations of plant extracts and their antioxidant activity of a multicomponent herbal medicine with antiallergic effect

Combinations of medicinal plants ensure the collective work several active components, which can lead to an additive or synergistic effect. We have chosen bur-marigold-calendula-hawthorn combination obtain antiallergic herbal medicine, in bur-marigold is main plant, calendula a helper plant that helps fight against accompanying symptoms, and hawthorn harmonizes action first 2 plants.
 The aim – study possible interactions multicomponent preparation by calculating correlation between content polyphenols various combinations extracts their antioxidant activity.
 Both individual herb, flowers leaves combined target extract with ratio drugs (6:3:1) were obtained. Two three component ompositions obtained mixing appropriate ratios. was determined SPhU 2.0, 2.8.14. activity neocuproin method. Pearson Correlation used calculate relationship maximum amount found (7.2%), bur-marigolg 5.5%, 3.4%. When adding extract, expected decrease, thus effect observed; for /hawthorn 1:0.5, increase (110.6%) observed compared value, may be synergism; calendula/hawthorn, observed. For 3-component combinations, it only bur-marigold/calendula/hawthorn 1:0.5:0.5 showed greater (112%) than all others within limits variations (± 10%) components. using coefficient, strong positive found.
 studied. In 2-component when determining activity, assumption made about ability synergism bur-marigold/hawthorn 1:0.5. All analyzed compositions A activity.